Interesting Cancer News

Of course, me being the big medical nerd that I am, I am fascinated by advances in medicine and there were two interesting discoveries of late that got my mind brewing about new medical thrillers and what this could mean for cancer treatment.

First of all, I have to give a shout out to Grey’s Anatomy who had a recent plot line of using genome therapy to cure a child with Severe Combined Immunodeficiency (aka SCID.) In order to deliver the therapy, Bailey used deactivated HIV virus to get it into the T-cells– and she did it without the parents permission. The child was cured but the parents were angry and threatened to charge her criminally with assault and battery. Which, by the way, can happen to a healthcare provider if they do something to a patient without their consent.

But I digress . . .

Not soon after this story line was a news piece about how a researcher used a mega dose of measles virus (enough to inoculate 10 million people) to cure a woman’s cancer. She became ill within minutes with a headache and over several hours suffered shaking, vomiting and a fever of 105 degrees.

Then, something interesting began to happen at hour thirty-six, a visible tumor on her forehead started shrinking and eventually disappeared and so did the other tumors in her body until they could not be found.

Evidently, using viruses as cancer treatment (oncolytic viral therapy) has been used since the 1950s but this is the only case where it has been successfully used in disseminated cancer.

The article states they learned two things– a big dose is needed and the patient doesn’t have to have antibodies to the virus.

Sadly, it only worked in one of the two patients injected so further study and more clinical trials need to be complete.

In other cancer news– evidently there has been some thought in cancer circles that there are “cancer stem cells” and even when you get most of the cancer during treatment, if these “mother stem cells” still exist for the cancer, this leads to reoccurrence and metastasis.  The hope is that by killing off the mother cells– you will get a cure for cancer. At this point in time, they’ve been located in blood cancers but the hope is that they exist for all cancer types and targeting these mother stem cells of cancer could provide a new and more effective avenue for treatment.

Medicine is cool.

What do you think about these discoveries? Do they generate in book plots in your mind? 

Retraction and an Apology

Hello all,

This is one retraction and apology I am very glad to have to write.

The article I had posted here today highlighting that the NHS had relaxed its rules regarding hand washing and Muslim care providers is not entirely true. I had concerns about this information as stated in the piece because it was mainly posted in conservative leaning websites. For me, if only one ideology carries the story (right or left) then it’s likely agenda driven anyway.

However, I had found the article as well at the Mail Online. I actually got a tweet from someone that stated those that live there find this paper highly unreliable.

So, I did some more checking and found this fact sheet that states that the dress rules were relaxed for Muslim care providers but not when they were caring for patients. They still must adhere to strict hand washing guidelines in those instances which makes me a very happy nurse.

Because medical accuracy is so important to me I am writing this retraction for the blog post’s inaccuracy and I sincerely apologize to anyone who was distressed by this particular blog post.

And I’m really happy for patients that this is not true.

Jordyn

Up and Coming

Hello Redwood’s Fans!

My love affair with Spring has been short lived because now it is TOO HOT! We moved from the midwest for this very reason– the heat and humidity– although Colorado doesn’t have that compared to the midwest. What I’ve learned is that my temperature comfort zone is very narrow.

What are you guys doing this summer? Any exciting plans?

For you this week:

Thursday: Cool cancer news. I know– those two words should not go together but you’ll definitely want to read this post for some interesting advances in cancer therapy.

Hope you have a great week.

Jordyn

Oklahoma’s Bothced Execution

I have to say– this is probably something your state doesn’t want to be known for. Last post, I discussed how EU pharmaceutical companies are refusing to allow their drugs to be used in executions.

More recently, was the botched execution of Oklahoma prisoner, Clayton Lockett.

What’s interesting is that in Oklahoma, the drug cocktail was kept “secret” by law and therefore was prohibitive in allowing the prisoner’s lawyer to file a cruel and unusual claim because they didn’t actually know what they were using. Even though the law was deemed unconstitutional, Clayton only had one month left to live and the Oklahoma Court of Criminal Appeals refused to stay the execution.

For the first time, the Oklahoma Supreme Court issued a stay but got so much political pressure that it reversed itself two days later.

It’s hard to piece together exactly what went wrong, but in this CNN account, the IV “blew” which means the vein ruptured and the medication likely went into the tissue versus staying in the venous system which likely delayed the onset of the medication. Reports state death ensued approx 45 minutes after the first drug was given.

They stopped the process but the prisoner succumbed to a heart attack. In my medical opinion, this was caused by the potassium injection.

What is complicating death by lethal injection is the “preferred” drugs for sedation cannot be used due to a mandate by EU pharmaceutical companies so alternatives for the sedative drug are trying to be found.

In the Oklahoma situation– it says the drugs are administered simultaneously by three different executioners. From a medical standpoint– this probably isn’t wise. A step-fold process would be better. If given one at a time, there would be less pressure on the line and less chance the vein would blow and you could ensure the sedative worked prior to administering the subsequent drugs making for a more “humane” execution.

Because of the problems now with lethal injection, a Utah State Representative is proposing the return of the firing squad

What do you think of the death penalty? Which method do you think is most “humane”?

European Drug Companies Halt Use of Drugs for Lethal Injection

 As a medical provider, I’ve seen drugs used on-label (approved by the FDA) and off-label (uses not approved by the FDA.) I’ve seen people misuse their prescribed medications and I’ve seen illegal drug use.

What’s interesting is that European drug companies are now using a moral standard for supplying drugs to the US— and that is they don’t want them used in executions.

First of all, what are the drugs used in an execution?

1. An anesthetic. This puts the prisoner to sleep.
2. A paralyzing agent. Which stops muscles from working including the muscles of respiration.
2. Potassium Chloride. Which stops the heart from beathing.

The issue with European drug companies was using their drugs to anesthetize prisoners for execution and they began prohibiting the sale of these drugs to prisons or to distribution companies that would then sell them to prisons.

This issue became more intense last fall when the company that manufactures Propofol (which has been blamed for Michael Jackson’s death) refused all US sale when they found out it was going to be used in an execution. However, Propofol is widely used in hospitals as sedation for shorter procedures. Its effects wear off quickly which allow patients to wake up sooner from their procedure and subsequently, go home sooner as well.

This ended up not happening to the point where it affected patient care but the EU pharmaceutical companies stand firm in not allowing their drugs to be used for executions.

What about you? Do you think a company should be allowed to use their moral standard when it comes to their product?  

Up and Coming

Hello Redwood’s Fans!

How’s your week going? Mine– enjoying the suspense part of Spring. Dark, stormy days.

I tend to not like sunshine. It’s too bright. Too cheery. I think because of this, God gave me an uber-optimist, bright and shiny child and a border cut from the same cloth who both LIKE sunshine. If I had to pick an animal I’m most like it would probably be a bat. Needless to say when I posted last week that Spring was my third favorite season– this led to utter shock to this border.

And then I explained. Thunderstorms. Rain. Lightening. It’s a marvel of nature and why I like spring. I mean, the new flowers are cool, too.

How about you? What’s your favorite part of spring?

This week it’s all about executions. There’s been quite a bit of news surrounding executions lately and it’s an interesting topic to explore. Do you think a drug company should be able to restrict the use of their medication for something they find objectionable? How would you feel about the return of firing squads?

Hope you’ll take in these posts and let me know your thoughts.

Have a great week!

Jordyn

Genetic Haemochromatosis: The Silent Killer


Genetic Hemochromatosis (GH) is a hereditary disorder causing the body to retain the trace mineral iron over and above its requirements. Without iron we couldn’t survive – its instrumental in the transportation of oxygen around the body; but too much iron kill. As the body cannot expel excess iron, it deposits it around our organs — mainly in the liver, pancreas, heart, endocrine glands, and joints, where it turns into a poison.
The subject is close to my heart, having been diagnosed with Genetic Hemochromatosis 10 years ago. I decided to write a humorous spoof thriller to increase awareness, raise funds and bring humor; I believe laughter is the best medicine. ‘The Unexpected Consequences of Iron Overload,’ is a paranormal, romantic, spoof thriller, with 100% of profits being donated to the Hemochromatosis Society.
Jimmy has absorbed iron and is now magnet. After a significant event in which he saves Barbara, the woman of his dreams, from possible death Jimmy realises he can control his magnetism. His life is further complicated after coming to the attention of the KBG – they are interested in all things paranormal, and the CIA who are determined to stop the Russians. Sheila further complicates life for Jimmy. Her father is Irish though she was born in Australia. Unbeknownst to her she has Haemochromatosis and is magnetic but of course, from the Southern hemisphere her polarity is reversed. 
For a disorder that few have heard of, it is surprisingly common. In Europe an estimated one in 200 have the genes linked to it — that’s 3.7 million people.  The Hemochromatosis Society — a charity founded and chaired by Janet Fernau, MBE says “people are suffering from entirely preventable diseases and even facing premature death because of a lack of awareness and testing.” 
Left untreated, this insidious condition causes individuals to develop life-threatening illnesses like diabetes, liver cirrhosis, cancer, arthritis, and heart disease.  The treatment is simple and cheap. The only way to remove iron from the body is via the blood – venesection.  Every pint removed takes with it 200mg of iron and lowers ferritin levels by 25 as the body starts to use the excess stored iron to make new red blood cells.
Hemochromatosis Society – www.haemochromatosis.org.uk – has as host of resources for people who have the condition.
The preface to The Unexpected Consequences of iron overload is a good layman’s introduction to the subject. In addition, a list of worldwide support groups/resources are included in my book.

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At age 52 James Minter was diagnosis with hemochromatosis. He is one of the lucky ones: he found out in time, and has no long-term organ damage. Researching the condition, he discovered there are millions of people who are carriers or have the disorder. The majority are unaware. The opportunity to stop unnecessary suffering is great. As a fiction writer in the humor genre, James wanted to use his creativity to bring hemochromatosis to the fore. He wrote The Unexpected Consequences of Iron Overload.  This is a light-hearted paranormal, romantic, spoof thriller with a serious message. Using the book he spends much of his time raising awareness of hemochromatosis via social media, blogging, presentations, press releases and radio interviews.

Dianna T. Benson: A Son’s Tale of Traumatic Brain Injury


The term concussion is well known. The medical field refers to a concussion as a TBI – Traumatic Brain Injury. Contact sports are one of the top causes of a TBI, another are MVCs – Motor Vehicle Collisions.
My teenaged son has endured four concussions. The first two as a goalie for the Junior Hurricanes and the third in a MVC. The first one took him out of school for a month and hockey for three months. The second, a year later, was more mild, which is unusual. Typically, a patient suffers a more severe TBI the second time. In the MVC, a classmate was driving them to school when another car struck them. This third TBI ended my son’s hockey career, preventing him from attending the Junior Hockey draft in Canada Spring of 2013.
The problem wasn’t simply that this was his third concussion, although that in itself is a strong reason to end a contact sport career. With this third TBI, a neurologist evaluated him versus just the concussion clinic MDs who’d treated him with the first two. Not only was it his third TBI, but his symptoms were extremely severe, which didn’t make sense to me – the details of the MVC didn’t suggest such injuries for my son: 1) None of the others involved in the crash suffered any injuries 2) No air bags deployed 3) Vehicle damage was minor. As an EMT for nearly a decade, I wondered about underlining health conditions in my son. I also considered he had not fully recovered from the first two concussions and was in denial about his symptoms in order to play hockey.
Sure enough, the neurologist diagnosed my son with hyper-mobile joints (something I already knew but wasn’t aware of the danger with contact sports.) The MD also diagnosed him with mild CP (cerebral palsy), a diagnosis that made sense to me since my son was born in respiratory arrest and was non-verbal and had spasticity until over age two. Both diagnosis are a recipe for injury, especially in contact sports. The MD gently told my son he was done playing goalie forever – it was devastating and crushed him. Understanding his hockey career was over, he admitted he’d ignored symptoms because he had a shot to play Junior Hockey, college hockey, and possibly professional hockey. A life-long athletic competitor myself, I completely understood the denial that led him to ignore his body.
Hyper-mobile joints, while creating an incredibly athletic body, are highly susceptible to any musculoskeletal injury in that individual. For my son, after two TBIs in a contact sport, his hyper-mobile neck was easily and severely whip-lashed in the MVC, jostling his brain fiercely, causing all his concussion symptoms to return and more heightened than ever.
Ten months after the car accident, the fourth TBI occurred December 2013 just days after the neurologist cleared my son to return to his life minus contact sports. The neurologist gave my son the green light to snowboard. That December day on the mountain, my son didn’t even hit his head and he sustained no head trauma – simply snowboarding jostled his brain enough to cause another TBI.   
Even though he’s extremely athletic, my son’s body shouldn’t do what it can to do. The risk of permanent brain damage and partial or full paralysis is too high for him– something he now understands. I described it to him as this: When Cam Ward (the goalie for the NHL team Carolina Hurricanes) is playing goalie, his body is naturally like a SUV of protection in a MVC. Whereas, for my son, his body is like a motorcycle in a MVC – no protection.
Until Spring 2015, my son is restricted from doing anything with speed, wheels, height or repetition (basically everything fun.) This next year his brain will heal, then little by little he can attempt things (no contact sports ever, though) to see how his body responds. At 6’7” in height and extremely athletic, he appears a medically sound seventeen-year-old, but inside his body tells a different story. 

    

God works in amazing ways and this is my son’s blessing. Since cerebral palsy only affects motor function, and none of the four TBIs caused him any loss of cognitive abilities, he’s still as annoyingly brilliant as ever and is anxious to head off to college this fall. For now, his goal is to graduate medical school with a degree in neurology and become a neurosurgeon since he feels (understandably so) he can relate to patients’ symptoms with head trauma. 
***********************************************************************


 Dianna Torscher Benson is a 2014 Selah Award Finalist (winners not yet announced), a 2011 Genesis Winner, a 2011 Genesis double Semi-Finalist, a 2010 Daphne de Maurier Finalist, and a 2007 Golden Palm Finalist. In 2012, she signed a nine-book contract with Ellechor Publishing House. She’s the author of The Hidden Son, her debut novel. Final Trimester is her second release.
After majoring in communications and a ten-year career as a travel agent, Dianna left the travel industry to earn her EMS degree. An EMT and a Haz-Mat and FEMA Operative since 2005, she loves the adrenaline rush of responding to medical emergencies and helping people in need.
Dianna lives in North Carolina with her husband and their three children. 
Her releases are available wherever books are sold. Below are the links to Final Trimester at the three largest booksellers:

 

Up and Coming

Hello Redwood’s Fans!

How has your week been? Good I hope and I hope you are starting to experience the Spring warm-up and that all your snow is safely melting and not flooding you out.

I like the newness of spring. The blooming flowers and still slightly cool air. It’s my third favorite season right behind fall and winter.

What’s your favorite thing about spring?

For you this week . . .

I have some fabulous guest bloggers coming up.

Tuesday: Dianna Benson (who was recently nominated for a Selah Award!) will be guest blogging on a personal level about her son’s traumatic brain injury.

Thursday: James Minter stops by to talk about his personal experience with genetic haemochromatosis.

Hope you all have a fabulous week!

Author Question: Assault Injuries

Author Question: My MC, a 17 year old female, is beaten up by her father. He was drunk, angry, so backhanded her across the face, which knocked her into a bookcase. Then while she was on the floor he kicked her repeatedly with sharp-toed cowboy boots, though runs out of steam fairly quickly and goes off to his bedroom. (She managed to curl herself into a ball to protect her internal organs.)

So right now this is what I’m looking at for her injuries:

1. Mild concussion (from hitting a shelf with her head — this would also possibly produce a small cut/gash because the edge of the shelf is sharp.)
2. Bruising to the face (from where he backhanded her.)
3. Broken ribs (I have 3 for now — is that too much?)
4. Pneumothorax from one of the ribs — just punctured, NOT collapsed.
5. Crack in the mid-shaft humerus of her right arm (from being kicked.)
Lots of bruising (obviously.)
First of all, are these injuries plausible given the scenario?
Jordyn Says:

These are a “good” array of injuries that would be plausible as a result of this type of beating. However, you can’t have a punctured lung without some amount of air getting out. It may be a small amount that would not require chest tube placement but there would likely be some if the lung were “punctured”. That’s likely the only way the medical team would know the lung was punctured was by evidence of air on the chest film. So, it might be easier to just go with cracked ribs.

Question: Would she be able to drag herself a few feet across the living room to get her father’s cell phone (left on a table), then crawl out the front door to the porch (the living room is just inside the front door)?

Jordyn: Yes, she should be able to do this.

Question: What might she experience? (Obviously pain, but I would assume she would have a great deal of trouble breathing, get oxygen-deprived, light-headed, nauseated …)

Jordyn: Yes, great pain. Rib fractures are quite painful and inhibit a person from taking full breaths so the patient tends to take more shallow breaths to prevent the pain. This could lead to lightheadedness (as well as the head injury), increased breathing rate, and increased heart rate (from pain, anxiety, fear.) If you go with a more serious lung injury (like a collapsed lung) then this could lead to lower oxygen levels, increased work of breathing, and diminished level of consciousness.
Question: What would be the ER procedure when she is brought in by her best friend’s family? It’s a very small-town medical center that barely qualifies as a hospital. When she’s brought in the staff is already busy on a multiple-patient car accident. Would it be plausible for the ER team to keep her waiting for a while after they take her back to an exam bay? Or would they worry about internal injuries and get her x-rayed right away? (As I said, it’s small-town, so goof-ups are possible.)

Jordyn: It depends on her presenting condition. If she’s awake, alert and oriented and doesn’t appear to be in imminent distress (such as significant difficulty breathing from whatever lung injury you choose) then it is plausible for her to wait while the car accident victims are being taken care of.

An ER evaluation is going to include vital signs, a medical history and history of the event, and then targeted x-rays for everything that hurts. So, chest film and right arm films at the least. Her head wound wound be irrigated and stitched closed if needed. Staples would be used if the wound is in the scalp. Tetanus shot needs to be within five years. CT of the head isn’t necessary for her head injury unless she has a focal neuro deficit (like I can’t move one arm) or unconsciousness. Depending on the x-ray results– her arm, at a minimum, would be placed in a sling until pain resolves. A stable fracture to the humerus can’t be splinted– only placed in a sling. 
This is the basics any ER should cover. 
This beating is a reportable injury so if the police haven’t been contacted– the ER staff should do so.
Question: The way I wrote it in the original draft was that she was taken to an exam bay right away, but then left to wait for a couple of hours. Then she was x-rayed and because of the pneumothorax, was taken back to a procedure/operating room to be intubated. The doc and a nurse came in while she was being prepped, to tell her friend’s family what her injuries are. (Would they put a cast on her arm? At what point would that happen, before or after the intubation?)
And then, how long would she be in the hospital?

Jordyn: Intubation is not the primary treatment for a collapsed lung– otherwise known as a pneumothorax. Placement of a chest tube is. This is what is required to safe the patient’s life. If you intubate and don’t place a chest tube the patient will die anyway because they will continue to accumulate air into their chest– especially with positive pressure ventilation– the machine forcing air into your lungs. Usually, just placement of a chest tube is enough.

A sling to her arm as noted above.
 

And then it depends (as with all things in medicine) how long the chest tube would stay in. I would say three-five days at the shortest. The lung has to re-expand, it has to stay expanded off suction, then the tube is removed. The patient is watched maybe one more day to make sure the air doesn’t come back.