Can Cadmium Poisoning Mimic Pregnancy?

Laura Asks:

Do you watch the television show Scorpion? If you do watch the show— you may not to read any further as this question may contain spoilers. In a recent episode, a character finds out that she is not pregnant, but instead is suffering from cadmium poisoning, which caused a late period and morning sickness. Is that possible?

Jordyn Says:

periodic-table-42115_1280Well, this is an interesting question. I had to do a bit of digging before coming to a conclusion.

The first research I did dealt extensively with chronic cadmium poisoning in a CEU article published by the CDC. For each of these effects from cadmium poisoning you could probably find research articles supporting and denying the correlation between cadmium and these disease processes so keep that in mind when you read this list.

Chronic exposure to cadmium fumes or dust, in some studies, have been associated with COPD, emphysema, and lung cancer. Animal studies show that exposure raises blood pressure.

The kidneys are the organs most affected by cadmium poisoning and the damage is dose related. Of interesting note was some studies that showed an increased likelihood of kidney stones in populations that had exposure to this heavy metal. Some studies have also shown bone lesions leading to fractures and osteoporosis.

In animals, cadmium in large doses crosses the placenta and led to birth defects, severe placental damage, and fetal death. This, however, has not been proven in the human realm but some studies show women exposed to cadmium may have a higher risk of premature labor.

Surprisingly, in this extensive article, nothing was said about cadmium’s effects on the menstrual cycle so I began to search just for that issue. I did come across this study which showed that cadmium could effect hormone levels involved with menses, but by mildly reducing some that are involved with pregnancy so, in essence, cadmium exposure shouldn’t mimic pregnancy.

All this being said, stress can always alter a woman’s cycle and nausea can be a sign of anxiety, but correlating these with cadmium exposure might be stretching it.

Treatment for Amnesia

Marissa Asks:

How do doctors proceed if they suspect amnesia? In my novel, the patient was brought to emergency after being found on the side of the road (in the snow.) The patient shows signs of physical torture: multiple rapes, bruises, lacerations, glass embedded mainly in his hands, hypothermia, and a cold (because obviously my character needs to be ill on top of everything).

burnout-384086_1920The patient has just woken up and had a panic attack. Been settled down. You asked for his name and he seemed uncertain as he gave his first name. You asked for his last name and the patient shook his head. What next? I mean obviously the glass would have been removed from his hands and a drip put in for painkillers but what next? Who does the nurse call? Or what does she ask now? And if memory loss is confirmed, how do they find out it’s amnesia like which SPECIFIC tests do they do? Who is contacted and brought in to liase?

I just sort of need a timeline rundown because my character is going to be going through that.

Jordyn Says:

Thanks so much for sending me your question. First of all, it sounds like this patient has a period of time where he is unconscious in the ER. You make it sound like he wakes up on his own and not in response to an exam by a doctor.

So an unconscious patient found with these injuries would have a CT scan of his head. Hypothermia could be determined simply by taking the patient’s temperature and warming him up with something as simple as warm blankets to more complex as heated IV fluids. Regarding the IV drip for pain— this is actually unlikely in the ER. This is referred to as a PCA pump (patient controlled analgesia) and I’ve never seen them used in any ER setting. Would we treat the patient’s pain? Yes. But, you might be surprised that we may choose not to use a narcotic (for many reasons) and instead try something like Toradol which is an IV form of an NSAID (which is in the same drug class as Ibuprofen.)

The glass embedded in his hands would be removed. The wounds irrigated and stitched closed if necessary. The lacerations would be treated the same way. Keep in mind, not all lacerations can be stitched closed if they’ve been open too long due to the risk of infection.This patient would also receive a tetanus booster if he hasn’t had one in the last five years (even if he can’t remember the last time he had a shot.) If anything looks infected, he would receive IV antibiotics.

If the patient wakes up and doesn’t know who he is (and doesn’t have any form of identification on him) then we would involve the police. Likely, they are probably already involved considering the circumstances— that he was found unconscious and beaten. Plus, you mention that the character has been raped several times so a sexual assault kit should be collected, but the patient’s consent is required, so we’d ask him if he wants this when he’s awake. Yet another reason the police would be involved.

If the doctors think the amnesia is related to a brain injury from the beating, they may just see if it improves with time.

I think it’s reasonable to admit this patient to the hospital and I speak a lot here about how it is actually rare to admit a patient with concussion, but considering the amnesia (it sounds like you want it to persist), the beating, the rapes, the wounds to his hands (as well as additional lacerations), and the hypothermia then some watchful observation is warranted. The doctors could consider a neurological and/or some type of psychological evaluation considering the circumstances of the case to see if his memory loss has a non-medical cause. Neuro might request an MRI of his brain to look for additional injuries not as easily discerned via CT scan.

In the end, if he never remembers, there’s little treatment to “correct” amnesia. This is good for the writer because you have a lot of leeway in what you want to happen to the character. Your time frame can be what you wish.

I think if he were stable in the hospital for a few days and the neurological/psychological evaluation didn’t warrant anything that required further inpatient treatment, he could be discharged home even if the amnesia persists with outpatient neurological follow-up and perhaps outpatient therapy if he consents.

Obviously the police would be very involved with this case.

Treatment for Multiple Concussions

This question came to me via my blog comments section.

Melody asks:

ice-hockey-1084197_1280I’m working on a hockey injury scenario where it’s the second hit to the head in a matter of a week, with a dull headache that hadn’t really went away to begin with (but he kept it to himself).

The second hit knocks him out for a few minutes, and he has confusion (and afterwards his demeanor is now very mean vs his nice personality before the hit). Would a second hit to the head with confusion, headache (and I’ll add nausea) require the CT scan? Would they be worried about brain swelling? Would they keep him or send him home with a headache that is extremely sensitive to every little sound (like a baby crying would send him through the roof)?

Jordyn Says:

Hi Melody. Thanks for submitting your question.

Yes, shame on this character for not being honest about his symptoms because if he had persistent headache then he shouldn’t be playing hockey until that resolves— like at all.

To be honest, if this is an adult patient, he’s going to get a CT scan of his head. In reality, CT scanning is much more prevalent in an adult ED (or community ED) than in a pediatric ER run by specially trained pediatric ER physicians. There are many reasons for this that I won’t go into here.

The CT scan will show if there is brain swelling. Depending on the extent of the brain swelling then medical decisions would be made. If mild, then admission to the hospital and observation. If significant, this could require specialized medications, going on a breathing machine, and ICU admission. Though if the swelling were severe the patient would likely be unconscious.

Sometimes headaches associated with concussion are treated like migraine headaches to see if that will improve the pain. But no, a patient wouldn’t be sent home until his headache pain is significantly improved, but it doesn’t have to be entirely gone. We just want to make sure it improves with medications. In some more serious medical conditions like brain tumors and brain bleeds, medications have little effect on the pain.

Then again, in this patient, CT scan would have shown whether or not these other things are present.

The Invention of the Stehoscope

I’m pleased to host historical author Ruth Axtell Morren as she posts about some of the medical research she did for her novel The Healing Season. You can find out more about Ruth by checking out her website.

the-healing-seasonThe stethoscope was invented by a French doctor, Laennec, in 1816. He discovered that you could hear sounds better from a certain distance, if there was something in between.

Back in those days, modesty many times prevented a (male) doctor from hearing a female patient’s heartbeat, because the only way you could hear it, was putting your ear up to the person’s chest.

Laennec rolled up some paper and put it against the patient’s chest and his ear to the other end, and voilà, the heartbeat sounded even clearer than if he had had his ear pressed against her.

I did a lot of research on medicine in the early nineteenth century for my regency novel, The Healing Season. 

I traveled to London and toured a museum that used to be an apothecary’s shop. It was part of the St. Guy’s/St. Thomas’s Hospital complex of that time. It was fascinating to see all the things used at that a time, especially the herbs and how pills were made.

Another interesting thing I found about that period was that at that time three kinds of medical practitioners existed: the physician, the apothecary and the surgeon.

The physician was the “profession,” only practiced by the aristocratic, university educated man. The apothecary was our pharmacist, but he learned through apprenticeship. Then there was the lowly surgeon, who evolved from the butcher, and he was strictly called in for cuts, broken bones or amputations and the few surgeries performed in those days (kidney stones being one). The physician hardly touched the patient, just prescribed tonics and dealt with “humors.” Medicine was more theoretical for this guy. The medicines he prescribed were made up by the apothecary.

What began happening, though, was that generally there weren’t that many physicians, especially away from the large cities, so apothecaries began taking over more and more of his duties. Surgeons, who also worked aboard navy ships and accompanied armies, began to perfect their technique on the battlefield (primitive triage). So, the professional lines began to blur, and the apothecary began to change into what would become the General Practitioner.

My story is about a surgeon. I also included his uncle and made him an apothecary. Some of the resources I used were Irvine Loudon’s Medical Care and the General Practitioner 1750-1850; Sherwin B. Nuland’s Doctors: The Biography of Medicine (excellent resource!); And Roy Porter’s Quacks, Fakers & Charlatans in Medicine.

This is a repost of a blog piece from November 19, 2010.

Medical Scene Diagnosis: Part 2/2

Today, I’m continuing my analysis of this medical scene. You can read the Part I here. Last post we learned this patient has been in a terrible car accident. We’ll resume with the physician entering the room to give the patient the low down. My comments will be in parentheses in red. I’m just focusing on the medical aspects, not grammar.

doctor-840127_1920-1The door opened, and an older gentleman in a lab coat walked briskly into the room. He checked the clipboard hanging from the end of the bed, noted the numbers on the monitors beside the bed that were tracking Tony’s vitals, and nodded, apparently pleased with what he saw. (Patient information is not kept in plain view. Clipboards hung on the end of the pateint’s bed with medical information is a HIPAA violation. HIPAA is the law that protects patient information.)

“I’m Dr McGregor, your attending physician. Arnold says you remember the accident?”

“Just parts of it.”

“Do you know what day it is?”

Tony squinted his eyes as he concentrated. “Well, I was driving home from San Jose late Saturday night or early Sunday morning. Other than that, I couldn’t say for sure.”

The doctor made some notes on the chart. (Many hospitals have gone to computer charting.)

Tony forced a grin. “Is that a good nod or a bad nod?”

Dr McGregor smiled at him, peering over the frames of his bifocals that perched on the end of his nose. “That’s good. It’s Sunday, actually. You haven’t lost much time. Considering the shape you were in when they brought you in here, that’s a miracle.”

Tony nodded gently. “Yes, sir.  God is in the business of miracles.”

The doctor peered intently at Tony, then smiled. “Apparently so. You should have died.”

Tony tried to shift, then winced at the waves of pain and nausea that threatened to engulf him.

The doctor moved closer to him and laid a restraining hand on his shoulder. “Take it easy. If you want to move, ask your nurse for help.”

“I’d like to have my head up.”

“I think we can arrange that.”

Dr. McGregor beckoned to Arnold, who came around to the head of the bed. Using his forearm, he propped Tony in the bed, adjusted the pillows, and nodded to the doctor, who stood at the end of the bed. Dr. McGregor pushed a button that raised the head of the bed. Arnold eased Tony back to the pillows and adjusted the sheet covering the lower half of his body. (I like that it’s a male nurse because it’s unusual. However, the doctor is coming across as very stereotypical. He’s older, long lab coat, bifocals on the end of his nose. What are some ways to vary this character to make him more unique?)

Tony gripped the handrails as another wave of nausea passed over him.

Dr McGregor patted his shoulder. “It’s normal to have some dizziness after a head injury, and you got a pretty nasty bang on the head.”

Tony held up one bandaged hand. “What else is wrong with me, Doc?”

Dr McGregor cleared his throat before proceeding. “Well, some lacerations on your hands from broken glass.” He flipped another page on the chart. “Same on your legs and back. A couple of broken ribs. The most serious injury is to your liver.” (Remember in the first part of this scene, the writer noted his legs and feet were unscathed. Maintain consistency with the patient’s injuries.)

“My liver?”

“Yes. You sustained a fairly serious tear in the accident. We were able to stop the internal bleeding, but right now your liver is not working well. In fact, the most recent blood panel we did shows it is deteriorating quickly.  I’m sorry, Tony.”

Instinctively Tony’s hand moved to his right side. He felt the edge of a bulky bandage that covered his flank, the incision still tender.

“A person can’t live without a liver, can they, doctor?”

“Your only option at this point is a liver transplant.” (I liked this a lot because I learned something new. As a confessed medical nerd, the first thing I thought was really? Went and looked and transplant can be used in cases of severe traumatic injury to the liver. Check it out here if interested.)

“A transplant?” Tony felt sweat running down the back of his neck and realized his face was wet, too. He ran a hand across his forehead.

“Yes. We’ll enter your name and statistics on the national database for liver transplants. To be honest, although your need is critical, your physical condition at this point in time would place you near the bottom of the list. In the meantime, you will have to stay in hospital so we can monitor your liver function.”

“Come on, Doc. Don’t beat around the bush with me. Not everyone who needs a liver transplant gets one, do they?”

“That’s true.”

“So, what other alternatives do we have?”

The doctor squinted. “I’m going to be honest. Your best bet at this point is to have a close family relative donate part of their liver. That will be the best match and can be accomplished a lot more quickly than a regular transplant.” (This is a place to be careful with your statements. After all, a stranger can come up as a perfect match. It may be better to say, “Your best hope for a new liver is to test a close biological relative like your mother, father and any siblings. If they prove to be a match, this process will be faster than waiting on the transplant list.”)

Tony’s heart sank. This didn’t sound good. “So what exactly are you saying?”

Dr. McGregor blinked at him myopically. “I don’t think you would survive the waiting. If you have any close relatives, you should call them.”

“My parents are dead and I’m an only child.”

“I’m so sorry, Tony. I wish I had better news. There’s not much more we can do at this point. Except pray.”

This writer deserves a lot of credit for setting up some nasty odds and conflict for this character. Strong work!! Do you have any other medical suggestions? 

Medical Scene Diagnosis: Part 1/2

This medical scene was submitted by a fellow writer who wanted some critique and agreed to allow me to post my suggestions leaving her name off the piece. The scene begins with a victim of a motor vehicle collision coming into the ER. His car rolled several times during the accident. What follows is her scene. My thoughts will be in parentheses at the end of the sentence in red. I’m only going to comment on the medical accuracy. Grammar editing is not the focus.

crash-1308575_1920Tony screamed out to God, and flung his hands over his face. Rough hands grabbed his hands as he tried to pry off whatever was smothering him. (This is good as patients often feel like an oxygen mask is smothering. Kids particularly aren’t fond of them.)

“Hey, take it easy. You’re all right. You need that oxygen.”

Tony opened his eyes, blinking rapidly in the bright lights. As his blurred vision came into focus, he tried to see who was holding his hands.

Blue scrubs. Dark face. The whitest of teeth. Name tag. Arnold.

Tony tried to speak, but his throat was dry. Arnold reached over, raised the mask on Tony’s face, and placed something cold and hard in his mouth. Making sure the mask was securely replaced, he sat back in his chair. (In the initial evaluation of a trauma patient in the ER, a patient is never given anything by mouth until it is ruled out whether or not they need surgery. The more the stomach is empty, the less likely the risk of aspiration during intubation. In this situation, aspiration would refer to inhaling vomit into your lungs while the endotracheal tube is placed. Aspiration can mean different things in the medical arena. And I also don’t know too many nurses who actually sit vigilant at a patient’s bedside.)

“It’s an ice chip. It’s all you can have right now.” (I know, we’re mean. But not even ice chips.)

Tony nodded his gratitude and slowly savored the small chip. It may have just been ice, but at that moment, it was like ambrosia to his parched throat.

Swallowing carefully past the pain in his throat, Tony lifted the mask and tried again. “Where am I?”

“You keep that mask in place. You can talk through it just fine.”

He waited until Tony complied before continuing. “You’re in the Regional Medical Center in San Jose.”


Arnold’s smile faded. “Yes. Doctor said you’re lucky to be alive.”

Tony nodded towards the container of ice. Arnold placed another chip in Tony’s mouth, replaced the mask, then set the cup where he could reach it on the bedside table.

“Where is the doctor?”

“I’ll go have him paged.” Arnold rose and left the room. (This is a situation where it is reasonable for a nurse to give the patient an update on his status and condition without needing to page the doctor. I may say something like, “Your leg is broken, but your other tests looks good. I’ll let the doctor know you’re awake and he’ll come in and talk things over with you in more detail.” Also, in the ER, doctors are generally present, and there may not be a need to have them paged. This can be very unit specific so you’d have some latitude as a writer.)

Tony surveyed his situation, beginning with his toes, and moving up to his hands. While he was achy all over, his feet and legs seemed to be unscathed. His chest and abdomen hurt, burning all the way through to his spine, and were heavily bandaged. (Saying his feet and legs are unscathed may be reaching a little. Remember, he rolled his car several times. At a minimum, there should be some bruising, cuts, or abrasions.)

His hands were bandaged but usable, and he took this opportunity to pop several chips into his mouth, crunching them to make them go down faster. Feeling with his hands, he knew his head was bandaged. Vaguely he remembered blood running into his eyes.

We’ll resume the analysis of this medical scene next post. Any other medical aspects you would change?

Drug Warning: Flakka Insanity

There is a new drug on the market— not a legal drug, but a new synthetic drug called Flakka that is creating havoc in south Florida and could be coming to your hometown.

What’s causing concern among law enforcement is that Flakka addiction became endemic in Broward County in a matter of months versus drugs like cocaine that took decades.

Flakka (alpha-PVP) is a synthetic crystal manufactured in China and sold via the internet. It arrived on the scene in Florida in 2014. It is ten times stronger than cocaine and far cheaper that cocaine, crack, and heroine.

Users of Flakka can suffer from dementia, psychosis, and paranoia. One of the biggest side effects is a state excited delirium which causes users to feel invincible yet deathly afraid. In this state, they can exhibit superhuman strength where it could take six to eight police officers to restrain them. Excited delirium leads to a rise in body temperature that can lead to heat exhaustion and even cardiac arrest. Some users have described this state as feeling like their “blood is on fire” and strip off their clothes because of it.

What’s also concerning law enforcement are the accidental and self-inflicted wounds that are killing Flakka users— more than forty deaths in the last year in Broward County alone.

Even more concerning is the after effects of the drug once a user stops. Some addicts suffer long term acute lapses in memory, difficulty articulating words, and poor concentration. Its effects on unborn babies is unknown, but one nine week premature infant boy has died with Flakka in his system.

There is no known reversal agent for the drug, only symptomatic support can be given.

Be on the lookout for this deadly drug in your community.

Information for this blog post largely came from the show Intervention which aired November 15, 2016.